In my OL, there's a team (actually in first place) using the 1964 Gaylord Perry as a starter. He started 19 games in '64, while relieving 25 times and pitching a total of 207 innings (fewer than 5 per appearance).
The results: In the first 5 innings of each appearance, totaling 164 innings in all, Perry has given up 50 runs.
After the 5th inning, 25 innings total, Perry's given up 59 RUNS!
That's some serious in-game fatigue!