One thing to look at doing, though it becomes really difficult to manage the fatigue, is to start the guys you want in at the end of the game, no matter how few minutes they play.
For example, on one of my teams, I have a 1499 minute Dennis Scott season and a 2021 minute Dale Ellis season. Scott does pretty much everything better than Ellis, so at the end of the game, when the extra few ast% or the extra 12 def (lol) might matter, I want him in. So I start him.
The trouble is, when you do this, it's extremely hard to get the starter to play close to his targetted minutes, and when you're only at about 18 minutes a game, a small variation of 4 or 5 minutes will drive your fatigue way down, especially during the first half of the season.
I have a similar problem with Donyell Marshall (1645) and Chuck Person (2131). What I've done is to start Marshall versus most teams, but versus those 3 or 4 that are completely hopeless (for them), I start Chuck and give Marshall a big minutes break, hoping to get him fresh for a team I need him against.
It's harder to do this with guys who play less and less minutes, but it's something you might want to look into trying.