I'm typically VERY sharing when it comes to info on this sim, but when it comes to a lot of stuff you're talking about, that's straight coaching, and that's something that you really need to learn by doing. I will say that when I initially set up my depth chart, I will set guys to play 2-4 minutes more per game than their rl/82 if I expect to win a lot & adjust according to how they're actually performing and depending on how tough my opponent is. It also depends on usage & how much of it I have. And other factors, depending on the type of league it is...
Basically, I can't tell you because of all of the variables & my belief that personal experience is paramount. Your example, I'd probably have Mutombo at 36 to start, lower it to 33 or 32 when he hits 99% fatigue or when I'm facing a crappy team. I'd up it to 38 or 40 vs a stronger opponent, or if I'm going against an especially critical game, I might play him the full 48 and then play him less the next few games. Like I said - so many variables. I adjust my depth chart after every game every day.