Is it just you in Coors or is it an all-Coors league? if everybody is in coors you need even more PA and IP, you might need 1600 IP. if your road games are in average stadiums I'd go 1520-1550 IP. If it's a DH league add about 30 innings.
draft much like any other stadium, solid pitching good D and the best hitters you can fit. walks are slightly devalued. speed is devalued but it does have its place. some people overdraft HR for coors but I dont think that's the best play. keep your key fielders at 100% or else they will make more errors.