From a historical perspective, President Obama will have the ACA, drawing down/end of Iraq/Afghanistan wars, and homosexual equality on his side.
From a negative, you'll have complete gridlock of congress (whether his fault or not, it's not a good thing), failure to "change Washington", failure to get immigration reform, probably the NSA situation, and maybe drone strikes.
I'm sure you'll come up with more negatives, but they'll be hyper partisan nothing-burgers.