I noticed this in a league where I had Coors as my home park. It's actually a progressive and the last two seasons, I've been well ahead in my division and then collapsed hard at the end. I suspect the reason is that most of my hitters, because of the extra ABs, were between 85-90%. They were still mashing, but their errors went up a bit and my pitchers were suddenly giving up more hits...which I suspect is a symptom of decreasing range in the field.
Others have also said fatigue hits hardest on defense, which makes sense if you think about it. In RL, a tired power hitter could still step up to the plate and bomb one, but his feet and hands would be a lot heavier in the field. You'd expect his range and reaction time to be slower, and maybe his focus a bit off as well. Those factors could have an effect on hitting as well, but it doesn't take as much energy to swing a bat as it does to field a position.